home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 461.8 KB |
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MacOS 8.1
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Win98
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DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
|00000000| 1a 44 50 31 2e 31 00 00 | 00 00 00 00 00 05 64 00 |.DP1.1..|......d.|
|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 9c 05 00 00 |......00|........|
|00000020| 8f 14 00 00 30 31 00 00 | 00 01 2b 1a 00 00 3a 13 |....01..|..+...:.|
|00000030| 00 00 30 32 00 00 00 01 | 65 2d 00 00 5d 12 00 00 |..02....|e-..]...|
|00000040| 30 33 00 00 00 01 c2 3f | 00 00 b0 10 00 00 30 34 |03.....?|......04|
|00000050| 00 00 00 01 72 50 00 00 | d5 15 00 00 30 35 00 00 |....rP..|....05..|
|00000060| 00 01 47 66 00 00 1c 18 | 00 00 30 36 00 00 00 01 |..Gf....|..06....|
|00000070| 63 7e 00 00 55 0c 00 00 | 30 37 00 00 00 01 b8 8a |c~..U...|07......|
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|000000c0| 00 00 00 01 df ee 00 00 | c7 19 00 00 31 33 00 00 |........|....13..|
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|00000310| 52 04 04 00 95 12 00 00 | 35 35 00 00 00 01 e7 16 |R.......|55......|
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|00000330| 14 12 00 00 35 37 00 00 | 00 01 df 35 04 00 50 0f |....57..|...5..P.|
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|00000400| 05 00 63 11 00 00 37 32 | 00 00 00 01 49 26 05 00 |..c...72|....I&..|
|00000410| 28 16 00 00 37 33 00 00 | 00 01 71 3c 05 00 4f 0e |(...73..|..q<..O.|
|00000420| 00 00 37 34 00 00 00 01 | c0 4a 05 00 06 11 00 00 |..74....|.J......|
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|00000440| 00 00 00 01 13 69 05 00 | 50 15 00 00 37 37 00 00 |.....i..|P...77..|
|00000450| 00 01 63 7e 05 00 42 11 | 00 00 37 38 00 00 00 01 |..c~..B.|..78....|
|00000460| a5 8f 05 00 da 11 00 00 | 37 39 00 00 00 01 7f a1 |........|79......|
|00000470| 05 00 ba 12 00 00 38 30 | 00 00 00 01 39 b4 05 00 |......80|....9...|
|00000480| f7 12 00 00 38 31 00 00 | 00 01 30 c7 05 00 41 13 |....81..|..0...A.|
|00000490| 00 00 38 32 00 00 00 01 | 71 da 05 00 f5 0c 00 00 |..82....|q.......|
|000004a0| 38 33 00 00 00 01 66 e7 | 05 00 de 0d 00 00 38 34 |83....f.|......84|
|000004b0| 00 00 00 01 44 f5 05 00 | b4 0b 00 00 38 35 00 00 |....D...|....85..|
|000004c0| 00 01 f8 00 06 00 19 19 | 00 00 38 36 00 00 00 01 |........|..86....|
|000004d0| 11 1a 06 00 11 0d 00 00 | 38 37 00 00 00 01 22 27 |........|87...."'|
|000004e0| 06 00 db 12 00 00 38 38 | 00 00 00 01 fd 39 06 00 |......88|.....9..|
|000004f0| 81 11 00 00 38 39 00 00 | 00 01 7e 4b 06 00 65 10 |....89..|..~K..e.|
|00000500| 00 00 39 30 00 00 00 01 | e3 5b 06 00 5c 11 00 00 |..90....|.[..\...|
|00000510| 39 31 00 00 00 01 3f 6d | 06 00 c5 0f 00 00 39 32 |91....?m|......92|
|00000520| 00 00 00 01 04 7d 06 00 | 18 21 00 00 39 33 00 00 |.....}..|.!..93..|
|00000530| 00 01 1c 9e 06 00 44 1d | 00 00 39 34 00 00 00 01 |......D.|..94....|
|00000540| 60 bb 06 00 b5 13 00 00 | 39 35 00 00 00 01 15 cf |`.......|95......|
|00000550| 06 00 d1 1a 00 00 39 36 | 00 00 00 01 e6 e9 06 00 |......96|........|
|00000560| 27 1a 00 00 39 37 00 00 | 00 01 0d 04 07 00 4d 0f |'...97..|......M.|
|00000570| 00 00 39 38 00 00 00 01 | 5a 13 07 00 64 12 00 00 |..98....|Z...d...|
|00000580| 39 39 00 00 00 01 be 25 | 07 00 83 11 00 00 00 00 |99.....%|........|
|00000590| 00 00 00 00 41 37 07 00 | 00 00 00 00 24 55 6e 69 |....A7..|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 36 37 30 30 7d |que_ID{Y|RB06700}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 44 72 75 67 2d 49 6e |..$Title|{Drug-In|
|000005c0| 64 75 63 65 64 20 4c 65 | 66 74 20 56 65 6e 74 72 |duced Le|ft Ventr|
|000005d0| 69 63 75 6c 61 72 20 46 | 61 69 6c 75 72 65 20 69 |icular F|ailure i|
|000005e0| 6e 20 50 61 74 69 65 6e | 74 73 20 57 69 74 68 20 |n Patien|ts With |
|000005f0| 50 75 6c 6d 6f 6e 61 72 | 79 20 44 69 73 65 61 73 |Pulmonar|y Diseas|
|00000600| 65 3a 20 20 45 6e 64 6f | 6d 79 6f 63 61 72 64 69 |e: Endo|myocardi|
|00000610| 61 6c 20 42 69 6f 70 73 | 79 20 44 65 6d 6f 6e 73 |al Biops|y Demons|
|00000620| 74 72 61 74 69 6f 6e 20 | 6f 66 20 43 61 74 65 63 |tration |of Catec|
|00000630| 68 6f 6c 61 6d 69 6e 65 | 20 4d 79 6f 63 61 72 64 |holamine| Myocard|
|00000640| 69 74 69 73 7d 0d 0a 24 | 41 75 74 68 6f 72 7b 4e |itis}..$|Author{N|
|00000650| 69 6e 6f 2c 20 41 46 0d | 0a 42 65 72 6d 61 6e 2c |ino, AF.|.Berman,|
|00000660| 20 4d 4d 0d 0a 47 6c 75 | 63 6b 2c 20 45 48 0d 0a | MM..Glu|ck, EH..|
|00000670| 43 6f 6e 77 61 79 2c 20 | 4d 4d 0d 0a 46 69 73 68 |Conway, |MM..Fish|
|00000680| 65 72 2c 20 4a 50 0d 0a | 44 6f 75 67 68 65 72 74 |er, JP..|Doughert|
|00000690| 79 2c 20 4a 45 0d 0a 52 | 6f 73 73 69 2c 20 4d 41 |y, JE..R|ossi, MA|
|000006a0| 7d 0d 0a 24 41 66 66 69 | 6c 69 61 74 69 6f 6e 7b |}..$Affi|liation{|
|000006b0| 48 61 72 74 66 6f 72 64 | 20 48 6f 73 70 2c 20 48 |Hartford| Hosp, H|
|000006c0| 61 72 74 66 6f 72 64 2c | 20 43 6f 6e 6e 3b 20 55 |artford,| Conn; U|
|000006d0| 6e 69 76 20 6f 66 20 43 | 6f 6e 6e 65 63 74 69 63 |niv of C|onnectic|
|000006e0| 75 74 2c 20 46 61 72 6d | 69 6e 67 74 6f 6e 7d 0d |ut, Farm|ington}.|
|000006f0| 0a 24 53 75 62 6a 65 63 | 74 7b 56 65 6e 74 72 69 |.$Subjec|t{Ventri|
|00000700| 63 6c 65 20 6c 65 66 74 | 20 66 61 69 6c 75 72 65 |cle left| failure|
|00000710| 2c 20 64 72 75 67 2d 69 | 6e 64 75 63 65 64 2c 20 |, drug-i|nduced, |
|00000720| 69 6e 20 70 75 6c 6d 6f | 6e 61 72 79 20 64 69 73 |in pulmo|nary dis|
|00000730| 65 61 73 65 3b 20 4d 79 | 6f 63 61 72 64 69 74 69 |ease; My|ocarditi|
|00000740| 73 0d 0a 63 61 74 65 63 | 68 6f 6c 61 6d 69 6e 65 |s..catec|holamine|
|00000750| 2c 20 65 6e 64 6f 6d 79 | 6f 63 61 72 64 69 61 6c |, endomy|ocardial|
|00000760| 20 62 69 6f 70 73 79 20 | 6f 66 3b 20 4c 75 6e 67 | biopsy |of; Lung|
|00000770| 2c 20 70 75 6c 6d 6f 6e | 61 72 79 20 64 69 73 65 |, pulmon|ary dise|
|00000780| 61 73 65 20 76 65 6e 74 | 72 69 63 75 6c 61 72 0d |ase vent|ricular.|
|00000790| 0a 66 61 69 6c 75 72 65 | 2c 20 64 72 75 67 2d 69 |.failure|, drug-i|
|000007a0| 6e 64 75 63 65 64 20 6c | 65 66 74 3b 20 44 72 75 |nduced l|eft; Dru|
|000007b0| 67 2c 20 44 72 75 67 73 | 2d 69 6e 64 75 63 65 64 |g, Drugs|-induced|
|000007c0| 20 6c 65 66 74 20 76 65 | 6e 74 72 69 63 75 6c 61 | left ve|ntricula|
|000007d0| 72 20 66 61 69 6c 75 72 | 65 20 69 6e 0d 0a 70 75 |r failur|e in..pu|
|000007e0| 6c 6d 6f 6e 61 72 79 20 | 64 69 73 65 61 73 65 3b |lmonary |disease;|
|000007f0| 20 43 61 74 65 63 68 6f | 6c 61 6d 69 6e 65 43 61 | Catecho|lamineCa|
|00000800| 74 65 63 68 6f 6c 61 6d | 69 6e 65 20 6d 79 6f 63 |techolam|ine myoc|
|00000810| 61 72 64 69 74 69 73 2c | 20 65 6e 64 6f 6d 79 6f |arditis,| endomyo|
|00000820| 63 61 72 64 69 61 6c 20 | 62 69 6f 70 73 79 0d 0a |cardial |biopsy..|
|00000830| 6f 66 3b 20 42 69 6f 70 | 73 79 20 65 6e 64 6f 6d |of; Biop|sy endom|
|00000840| 79 6f 63 61 72 64 69 61 | 6c 20 6f 66 20 6d 79 6f |yocardia|l of myo|
|00000850| 63 61 72 64 69 74 69 73 | 2c 20 63 61 74 65 63 68 |carditis|, catech|
|00000860| 6f 6c 61 6d 69 6e 65 7d | 0d 0a 24 4a 6f 75 72 6e |olamine}|..$Journ|
|00000870| 61 6c 7b 43 68 65 73 74 | 7d 0d 0a 24 56 6f 6c 75 |al{Chest|}..$Volu|
|00000880| 6d 65 7b 39 32 7d 0d 0a | 24 50 61 67 65 7b 37 33 |me{92}..|$Page{73|
|00000890| 32 2d 37 33 36 7d 0d 0a | 24 44 61 74 65 7b 4f 63 |2-736}..|$Date{Oc|
|000008a0| 74 6f 62 65 72 20 31 39 | 38 37 7d 0d 0a 24 59 42 |tober 19|87}..$YB|
|000008b0| 56 6f 6c 7b 31 39 38 39 | 20 59 65 61 72 20 42 6f |Vol{1989| Year Bo|
|000008c0| 6f 6b 20 6f 66 20 4d 65 | 64 69 63 69 6e 65 2c 20 |ok of Me|dicine, |
|000008d0| 50 61 72 74 20 54 77 6f | 7d 0d 0a 24 43 68 61 70 |Part Two|}..$Chap|
|000008e0| 74 65 72 7b 31 34 2d 33 | 7d 0d 0a 24 59 42 45 64 |ter{14-3|}..$YBEd|
|000008f0| 69 74 6f 72 7b 44 72 73 | 2e 20 52 6f 67 65 72 73 |itor{Drs|. Rogers|
|00000900| 2c 20 44 65 73 20 50 72 | 65 7a 2c 20 43 6c 69 6e |, Des Pr|ez, Clin|
|00000910| 65 2c 20 42 72 61 75 6e | 77 61 6c 64 2c 20 47 72 |e, Braun|wald, Gr|
|00000920| 65 65 6e 62 65 72 67 65 | 72 2c 20 57 69 6c 73 6f |eenberge|r, Wilso|
|00000930| 6e 2c 20 45 70 73 74 65 | 69 6e 2c 20 61 6e 64 20 |n, Epste|in, and |
|00000940| 4d 61 6c 61 77 69 73 74 | 61 7d 0d 0a 24 54 61 62 |Malawist|a}..$Tab|
|00000950| 6c 65 7b 7d 0d 0a 24 43 | 6f 6d 6d 65 6e 74 61 74 |le{}..$C|ommentat|
|00000960| 6f 72 7b 52 2e 4d 2e 20 | 44 65 73 20 50 72 65 7a |or{R.M. |Des Prez|
|00000970| 2c 20 4d 2e 44 2e 7d 0d | 0a 0d 0a 43 6f 70 79 72 |, M.D.}.|...Copyr|
|00000980| 69 67 68 74 20 28 63 29 | 20 59 65 61 72 20 42 6f |ight (c)| Year Bo|
|00000990| 6f 6b 20 4d 65 64 69 63 | 61 6c 20 50 75 62 6c 69 |ok Medic|al Publi|
|000009a0| 73 68 65 72 73 2c 20 49 | 6e 63 2e 2c 20 31 39 38 |shers, I|nc., 198|
|000009b0| 39 0d 0a 0d 0a 31 39 38 | 39 20 59 65 61 72 20 42 |9....198|9 Year B|
|000009c0| 6f 6f 6b 20 6f 66 20 4d | 65 64 69 63 69 6e 65 20 |ook of M|edicine |
|000009d0| 28 52 29 0d 0a 0d 0a 50 | 61 72 74 20 54 77 6f 3a |(R)....P|art Two:|
|000009e0| 20 20 54 68 65 20 43 68 | 65 73 74 0d 0a 0d 0a 43 | The Ch|est....C|
|000009f0| 68 61 70 74 65 72 20 31 | 34 2d 2d 44 69 61 67 6e |hapter 1|4--Diagn|
|00000a00| 6f 73 69 73 20 61 6e 64 | 20 54 68 65 72 61 70 79 |osis and| Therapy|
|00000a10| 0d 0a 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |....----|--------|
|00000a20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a60| 2d 2d 2d 2d 0d 0a 44 72 | 75 67 2d 49 6e 64 75 63 |----..Dr|ug-Induc|
|00000a70| 65 64 20 4c 65 66 74 20 | 56 65 6e 74 72 69 63 75 |ed Left |Ventricu|
|00000a80| 6c 61 72 20 46 61 69 6c | 75 72 65 20 69 6e 20 50 |lar Fail|ure in P|
|00000a90| 61 74 69 65 6e 74 73 20 | 57 69 74 68 20 50 75 6c |atients |With Pul|
|00000aa0| 6d 6f 6e 61 72 79 20 44 | 69 73 65 61 73 65 3a 0d |monary D|isease:.|
|00000ab0| 0a 45 6e 64 6f 6d 79 6f | 63 61 72 64 69 61 6c 20 |.Endomyo|cardial |
|00000ac0| 42 69 6f 70 73 79 20 44 | 65 6d 6f 6e 73 74 72 61 |Biopsy D|emonstra|
|00000ad0| 74 69 6f 6e 20 6f 66 20 | 43 61 74 65 63 68 6f 6c |tion of |Catechol|
|00000ae0| 61 6d 69 6e 65 20 4d 79 | 6f 63 61 72 64 69 74 69 |amine My|ocarditi|
|00000af0| 73 0d 0a 0d 0a 4e 69 6e | 6f 2c 20 41 46 3b 20 42 |s....Nin|o, AF; B|
|00000b00| 65 72 6d 61 6e 2c 20 4d | 4d 3b 20 47 6c 75 63 6b |erman, M|M; Gluck|
|00000b10| 2c 20 45 48 3b 20 43 6f | 6e 77 61 79 2c 20 4d 4d |, EH; Co|nway, MM|
|00000b20| 3b 20 46 69 73 68 65 72 | 2c 20 4a 50 3b 20 44 6f |; Fisher|, JP; Do|
|00000b30| 75 67 68 65 72 74 79 2c | 20 4a 45 3b 0d 0a 52 6f |ugherty,| JE;..Ro|
|00000b40| 73 73 69 2c 20 4d 41 20 | 28 48 61 72 74 66 6f 72 |ssi, MA |(Hartfor|
|00000b50| 64 20 48 6f 73 70 2c 20 | 48 61 72 74 66 6f 72 64 |d Hosp, |Hartford|
|00000b60| 2c 20 43 6f 6e 6e 3b 20 | 55 6e 69 76 20 6f 66 20 |, Conn; |Univ of |
|00000b70| 43 6f 6e 6e 65 63 74 69 | 63 75 74 2c 20 46 61 72 |Connecti|cut, Far|
|00000b80| 6d 69 6e 67 74 6f 6e 29 | 0d 0a 43 68 65 73 74 20 |mington)|..Chest |
|00000b90| 39 32 3a 37 33 32 2d 37 | 33 36 2c 20 4f 63 74 6f |92:732-7|36, Octo|
|00000ba0| 62 65 72 20 31 39 38 37 | 0d 0a 2d 2d 2d 2d 2d 2d |ber 1987|..------|
|00000bb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000bc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000bd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000be0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000bf0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 0d 0a 41 62 |--------|--....Ab|
|00000c00| 73 74 72 61 63 74 0d 0a | 0d 0a 20 20 20 20 20 50 |stract..|.. P|
|00000c10| 61 74 69 65 6e 74 73 20 | 77 69 74 68 20 63 68 72 |atients |with chr|
|00000c20| 6f 6e 69 63 20 70 75 6c | 6d 6f 6e 61 72 79 20 64 |onic pul|monary d|
|00000c30| 69 73 65 61 73 65 20 6d | 61 79 20 68 61 76 65 20 |isease m|ay have |
|00000c40| 6c 65 66 74 20 76 65 6e | 74 72 69 63 75 6c 61 72 |left ven|tricular|
|00000c50| 20 66 61 69 6c 75 72 65 | 0d 0a 6f 66 20 6e 6f 20 | failure|..of no |
|00000c60| 61 70 70 61 72 65 6e 74 | 20 63 61 75 73 65 2e 20 |apparent| cause. |
|00000c70| 20 54 68 72 65 65 20 70 | 61 74 69 65 6e 74 73 20 | Three p|atients |
|00000c80| 68 61 64 20 6c 65 66 74 | 20 76 65 6e 74 72 69 63 |had left| ventric|
|00000c90| 75 6c 61 72 20 66 61 69 | 6c 75 72 65 20 77 69 74 |ular fai|lure wit|
|00000ca0| 68 20 6d 61 72 6b 65 64 | 0d 0a 69 6d 70 61 69 72 |h marked|..impair|
|00000cb0| 6d 65 6e 74 20 6f 66 20 | 63 61 72 64 69 61 63 20 |ment of |cardiac |
|00000cc0| 66 75 6e 63 74 69 6f 6e | 20 61 73 73 6f 63 69 61 |function| associa|
|00000cd0| 74 65 64 20 77 69 74 68 | 20 74 72 65 61 74 6d 65 |ted with| treatme|
|00000ce0| 6e 74 20 66 6f 72 20 73 | 65 76 65 72 65 20 63 68 |nt for s|evere ch|
|00000cf0| 72 6f 6e 69 63 0d 0a 6f | 62 73 74 72 75 63 74 69 |ronic..o|bstructi|
|00000d00| 76 65 20 70 75 6c 6d 6f | 6e 61 72 79 20 64 69 73 |ve pulmo|nary dis|
|00000d10| 65 61 73 65 20 28 43 4f | 50 44 29 2e 0d 0a 20 20 |ease (CO|PD)... |
|00000d20| 20 20 20 4f 6e 65 20 70 | 61 74 69 65 6e 74 20 68 | One p|atient h|
|00000d30| 61 64 20 73 65 76 65 72 | 65 20 61 73 74 68 6d 61 |ad sever|e asthma|
|00000d40| 2c 20 61 6e 6f 74 68 65 | 72 20 68 61 64 20 61 73 |, anothe|r had as|
|00000d50| 74 68 6d 61 74 69 63 20 | 62 72 6f 6e 63 68 69 74 |thmatic |bronchit|
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|00001d10| 4d 65 64 69 63 61 6c 20 | 50 75 62 6c 69 73 68 65 |Medical |Publishe|
|00001d20| 72 73 2c 20 49 6e 63 2e | 2c 20 31 39 38 39 0d 0a |rs, Inc.|, 1989..|
|00001d30| 0d 0a 31 39 38 39 20 59 | 65 61 72 20 42 6f 6f 6b |..1989 Y|ear Book|
|00001d40| 20 6f 66 20 4d 65 64 69 | 63 69 6e 65 20 28 52 29 | of Medi|cine (R)|
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|00001d60| 68 65 20 43 68 65 73 74 | 0d 0a 0d 0a 43 68 61 70 |he Chest|....Chap|
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|00001d90| 0a 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |.-------|--------|
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|00001db0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001dc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001dd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001de0| 2d 0d 0a 4f 70 65 6e 20 | 4c 75 6e 67 20 42 69 6f |-..Open |Lung Bio|
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|00001e00| 57 69 74 68 20 44 69 66 | 66 75 73 65 20 50 75 6c |With Dif|fuse Pul|
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|00001e30| 73 70 69 72 61 74 6f 72 | 79 20 46 61 69 6c 75 72 |spirator|y Failur|
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|00001e60| 65 72 74 69 65 2c 20 4d | 42 0d 0a 28 4d 61 79 6f |ertie, M|B..(Mayo|
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|00001e90| 72 20 44 69 73 20 31 33 | 37 3a 39 30 2d 39 34 2c |r Dis 13|7:90-94,|
|00001ea0| 20 4a 61 6e 75 61 72 79 | 20 31 39 38 38 0d 0a 2d | January| 1988..-|
|00001eb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001ec0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001ed0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001ee0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001ef0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 0d |--------|-------.|
|00001f00| 0a 0d 0a 41 62 73 74 72 | 61 63 74 0d 0a 0d 0a 20 |...Abstr|act.... |
|00001f10| 20 20 20 20 50 68 79 73 | 69 63 69 61 6e 73 20 6d | Phys|icians m|
|00001f20| 61 79 20 62 65 20 72 65 | 6c 75 63 74 61 6e 74 20 |ay be re|luctant |
|00001f30| 74 6f 20 70 65 72 66 6f | 72 6d 20 61 6e 20 6f 70 |to perfo|rm an op|
|00001f40| 65 6e 2d 6c 75 6e 67 20 | 62 69 6f 70 73 79 20 69 |en-lung |biopsy i|
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|00001f80| 79 20 66 61 69 6c 75 72 | 65 20 62 65 63 61 75 73 |y failur|e becaus|
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|000020b0| 48 67 20 77 68 69 6c 65 | 20 62 72 65 61 74 68 69 |Hg while| breathi|
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|00002160| 20 20 41 74 0d 0a 6c 65 | 61 73 74 20 31 20 73 70 | At..le|ast 1 sp|
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|00002390| 74 20 74 75 62 65 20 64 | 72 61 69 6e 61 67 65 2e |t tube d|rainage.|
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|00002850| 69 6e 20 74 68 65 20 31 | 39 38 36 20 59 65 61 72 |in the 1|986 Year|
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|00002870| 65 2e 20 5b 31 5d 20 20 | 4e 6f 20 64 65 61 74 68 |e. [1] |No death|
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|00002d20| 20 73 68 6f 75 6c 64 20 | 62 65 20 64 6f 6e 65 20 | should |be done |
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|00002d50| 52 2e 4d 2e 20 44 65 73 | 20 50 72 65 7a 2c 20 4d |R.M. Des| Prez, M|
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|00002fa0| 20 42 6f 6f 6b 20 6f 66 | 20 4d 65 64 69 63 69 6e | Book of| Medicin|
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|00003000| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00003020| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003030| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00003090| 0d 0a 43 6f 72 65 79 2c | 20 52 3b 20 48 6c 61 2c |..Corey,| R; Hla,|
|000030a0| 20 4b 4d 0d 0a 28 44 75 | 6b 65 20 55 6e 69 76 2c | KM..(Du|ke Univ,|
|000030b0| 20 44 75 72 68 61 6d 2c | 20 4e 43 29 0d 0a 41 6d | Durham,| NC)..Am|
|000030c0| 20 4a 20 4d 65 64 20 53 | 63 69 20 32 39 34 3a 33 | J Med S|ci 294:3|
|000030d0| 30 31 2d 33 30 39 2c 20 | 4e 6f 76 65 6d 62 65 72 |01-309, |November|
|000030e0| 20 31 39 38 37 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d | 1987..-|--------|
|000030f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003100| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003110| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003120| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003130| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 0d 0a 41 62 73 74 72 |-------.|...Abstr|
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|00004130| 34 2d 35 31 38 7d 0d 0a | 24 44 61 74 65 7b 4a 75 |4-518}..|$Date{Ju|
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|00004180| 7b 31 35 2d 31 7d 0d 0a | 24 59 42 45 64 69 74 6f |{15-1}..|$YBEdito|
|00004190| 72 7b 44 72 73 2e 20 52 | 6f 67 65 72 73 2c 20 44 |r{Drs. R|ogers, D|
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|000041b0| 42 72 61 75 6e 77 61 6c | 64 2c 20 47 72 65 65 6e |Braunwal|d, Green|
|000041c0| 62 65 72 67 65 72 2c 20 | 57 69 6c 73 6f 6e 2c 20 |berger, |Wilson, |
|000041d0| 45 70 73 74 65 69 6e 2c | 20 61 6e 64 20 4d 61 6c |Epstein,| and Mal|
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|00004200| 52 2e 4d 2e 20 44 65 73 | 20 50 72 65 7a 2c 20 4d |R.M. Des| Prez, M|
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|00004220| 74 20 28 63 29 20 59 65 | 61 72 20 42 6f 6f 6b 20 |t (c) Ye|ar Book |
|00004230| 4d 65 64 69 63 61 6c 20 | 50 75 62 6c 69 73 68 65 |Medical |Publishe|
|00004240| 72 73 2c 20 49 6e 63 2e | 2c 20 31 39 38 39 0d 0a |rs, Inc.|, 1989..|
|00004250| 0d 0a 31 39 38 39 20 59 | 65 61 72 20 42 6f 6f 6b |..1989 Y|ear Book|
|00004260| 20 6f 66 20 4d 65 64 69 | 63 69 6e 65 20 28 52 29 | of Medi|cine (R)|
|00004270| 0d 0a 0d 0a 50 61 72 74 | 20 54 77 6f 3a 20 20 54 |....Part| Two: T|
|00004280| 68 65 20 43 68 65 73 74 | 0d 0a 0d 0a 43 68 61 70 |he Chest|....Chap|
|00004290| 74 65 72 20 31 35 2d 2d | 49 6e 74 65 72 73 74 69 |ter 15--|Intersti|
|000042a0| 74 69 61 6c 20 4c 75 6e | 67 20 44 69 73 65 61 73 |tial Lun|g Diseas|
|000042b0| 65 0d 0a 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |e....---|--------|
|000042c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000042d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000042e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000042f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004300| 2d 2d 2d 2d 2d 0d 0a 48 | 69 73 74 6f 6c 6f 67 69 |-----..H|istologi|
|00004310| 63 20 44 69 61 67 6e 6f | 73 69 73 20 6f 66 20 45 |c Diagno|sis of E|
|00004320| 78 74 72 69 6e 73 69 63 | 20 41 6c 6c 65 72 67 69 |xtrinsic| Allergi|
|00004330| 63 20 41 6c 76 65 6f 6c | 69 74 69 73 0d 0a 0d 0a |c Alveol|itis....|
|00004340| 43 6f 6c 65 6d 61 6e 2c | 20 41 3b 20 43 6f 6c 62 |Coleman,| A; Colb|
|00004350| 79 2c 20 54 56 0d 0a 28 | 4c 44 53 20 48 6f 73 70 |y, TV..(|LDS Hosp|
|00004360| 69 74 61 6c 2c 20 53 61 | 6c 74 20 4c 61 6b 65 20 |ital, Sa|lt Lake |
|00004370| 43 69 74 79 3b 20 4d 61 | 79 6f 20 43 6c 69 6e 69 |City; Ma|yo Clini|
|00004380| 63 20 61 6e 64 20 46 6f | 75 6e 64 2c 20 52 6f 63 |c and Fo|und, Roc|
|00004390| 68 65 73 74 65 72 2c 20 | 4d 69 6e 6e 29 0d 0a 41 |hester, |Minn)..A|
|000043a0| 6d 20 4a 20 53 75 72 67 | 20 50 61 74 68 6f 6c 20 |m J Surg| Pathol |
|000043b0| 31 32 3a 35 31 34 2d 35 | 31 38 2c 20 4a 75 6c 79 |12:514-5|18, July|
|000043c0| 20 31 39 38 38 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d | 1988..-|--------|
|000043d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000043e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000043f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00005200| 61 74 65 7b 53 65 70 74 | 65 6d 62 65 72 20 31 39 |ate{Sept|ember 19|
|00005210| 38 37 7d 0d 0a 24 59 42 | 56 6f 6c 7b 31 39 38 39 |87}..$YB|Vol{1989|
|00005220| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 4d 65 | Year Bo|ok of Me|
|00005230| 64 69 63 69 6e 65 2c 20 | 50 61 72 74 20 54 77 6f |dicine, |Part Two|
|00005240| 7d 0d 0a 24 43 68 61 70 | 74 65 72 7b 31 35 2d 32 |}..$Chap|ter{15-2|
|00005250| 7d 0d 0a 24 59 42 45 64 | 69 74 6f 72 7b 44 72 73 |}..$YBEd|itor{Drs|
|00005260| 2e 20 52 6f 67 65 72 73 | 2c 20 44 65 73 20 50 72 |. Rogers|, Des Pr|
|00005270| 65 7a 2c 20 43 6c 69 6e | 65 2c 20 42 72 61 75 6e |ez, Clin|e, Braun|
|00005280| 77 61 6c 64 2c 20 47 72 | 65 65 6e 62 65 72 67 65 |wald, Gr|eenberge|
|00005290| 72 2c 20 57 69 6c 73 6f | 6e 2c 20 45 70 73 74 65 |r, Wilso|n, Epste|
|000052a0| 69 6e 2c 20 61 6e 64 20 | 4d 61 6c 61 77 69 73 74 |in, and |Malawist|
|000052b0| 61 7d 0d 0a 24 54 61 62 | 6c 65 7b 7d 0d 0a 24 43 |a}..$Tab|le{}..$C|
|000052c0| 6f 6d 6d 65 6e 74 61 74 | 6f 72 7b 52 2e 4d 2e 20 |ommentat|or{R.M. |
|000052d0| 44 65 73 20 50 72 65 7a | 2c 20 4d 2e 44 2e 7d 0d |Des Prez|, M.D.}.|
|000052e0| 0a 0d 0a 43 6f 70 79 72 | 69 67 68 74 20 28 63 29 |...Copyr|ight (c)|
|000052f0| 20 59 65 61 72 20 42 6f | 6f 6b 20 4d 65 64 69 63 | Year Bo|ok Medic|
|00005300| 61 6c 20 50 75 62 6c 69 | 73 68 65 72 73 2c 20 49 |al Publi|shers, I|
|00005310| 6e 63 2e 2c 20 31 39 38 | 39 0d 0a 0d 0a 31 39 38 |nc., 198|9....198|
|00005320| 39 20 59 65 61 72 20 42 | 6f 6f 6b 20 6f 66 20 4d |9 Year B|ook of M|
|00005330| 65 64 69 63 69 6e 65 20 | 28 52 29 0d 0a 0d 0a 50 |edicine |(R)....P|
|00005340| 61 72 74 20 54 77 6f 3a | 20 20 54 68 65 20 43 68 |art Two:| The Ch|
|00005350| 65 73 74 0d 0a 0d 0a 43 | 68 61 70 74 65 72 20 31 |est....C|hapter 1|
|00005360| 35 2d 2d 49 6e 74 65 72 | 73 74 69 74 69 61 6c 20 |5--Inter|stitial |
|00005370| 4c 75 6e 67 20 44 69 73 | 65 61 73 65 0d 0a 0d 0a |Lung Dis|ease....|
|00005380| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005390| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000053a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000053b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000053c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000053d0| 0d 0a 44 69 66 66 75 73 | 65 20 50 75 6c 6d 6f 6e |..Diffus|e Pulmon|
|000053e0| 61 72 79 20 48 65 6d 6f | 72 72 68 61 67 65 3a 20 |ary Hemo|rrhage: |
|000053f0| 20 41 6e 20 55 6e 63 6f | 6d 6d 6f 6e 20 4d 61 6e | An Unco|mmon Man|
|00005400| 69 66 65 73 74 61 74 69 | 6f 6e 20 6f 66 20 57 65 |ifestati|on of We|
|00005410| 67 65 6e 65 72 27 73 0d | 0a 47 72 61 6e 75 6c 6f |gener's.|.Granulo|
|00005420| 6d 61 74 6f 73 69 73 0d | 0a 0d 0a 54 72 61 76 69 |matosis.|...Travi|
|00005430| 73 2c 20 57 44 3b 20 43 | 61 72 70 65 6e 74 65 72 |s, WD; C|arpenter|
|00005440| 2c 20 48 41 3b 20 4c 69 | 65 2c 20 4a 54 0d 0a 28 |, HA; Li|e, JT..(|
|00005450| 4d 61 79 6f 20 43 6c 69 | 6e 69 63 20 61 6e 64 20 |Mayo Cli|nic and |
|00005460| 46 6f 75 6e 64 2c 20 52 | 6f 63 68 65 73 74 65 72 |Found, R|ochester|
|00005470| 2c 20 4d 69 6e 6e 29 0d | 0a 41 6d 20 4a 20 53 75 |, Minn).|.Am J Su|
|00005480| 72 67 20 50 61 74 68 6f | 6c 20 31 31 3a 37 30 32 |rg Patho|l 11:702|
|00005490| 2d 37 30 38 2c 20 53 65 | 70 74 65 6d 62 65 72 20 |-708, Se|ptember |
|000054a0| 31 39 38 37 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |1987..--|--------|
|000054b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000054c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000054d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000054e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000054f0| 2d 2d 2d 2d 2d 2d 0d 0a | 0d 0a 41 62 73 74 72 61 |------..|..Abstra|
|00005500| 63 74 0d 0a 0d 0a 20 20 | 20 20 20 57 65 67 65 6e |ct.... | Wegen|
|00005510| 65 72 27 73 20 67 72 61 | 6e 75 6c 6f 6d 61 74 6f |er's gra|nulomato|
|00005520| 73 69 73 2c 20 69 6e 20 | 74 68 65 20 61 62 73 65 |sis, in |the abse|
|00005530| 6e 63 65 20 6f 66 20 69 | 74 73 20 6f 74 68 65 72 |nce of i|ts other|
|00005540| 20 6d 61 6e 69 66 65 73 | 74 61 74 69 6f 6e 73 2c | manifes|tations,|
|00005550| 20 69 73 0d 0a 6e 6f 74 | 20 6f 66 74 65 6e 20 63 | is..not| often c|
|00005560| 6f 6e 73 69 64 65 72 65 | 64 20 69 6e 20 74 68 65 |onsidere|d in the|
|00005570| 20 64 69 66 66 65 72 65 | 6e 74 69 61 6c 20 64 69 | differe|ntial di|
|00005580| 61 67 6e 6f 73 69 73 20 | 6f 66 20 64 69 66 66 75 |agnosis |of diffu|
|00005590| 73 65 20 61 6c 76 65 6f | 6c 61 72 0d 0a 68 65 6d |se alveo|lar..hem|
|000055a0| 6f 72 72 68 61 67 65 2e | 20 20 54 77 6f 20 70 61 |orrhage.| Two pa|
|000055b0| 74 69 65 6e 74 73 20 77 | 69 74 68 20 57 65 67 65 |tients w|ith Wege|
|000055c0| 6e 65 72 27 73 20 67 72 | 61 6e 75 6c 6f 6d 61 74 |ner's gr|anulomat|
|000055d0| 6f 73 69 73 20 65 78 70 | 65 72 69 65 6e 63 65 64 |osis exp|erienced|
|000055e0| 20 66 75 6c 6d 69 6e 61 | 6e 74 0d 0a 61 6c 76 65 | fulmina|nt..alve|
|000055f0| 6f 6c 61 72 20 68 65 6d | 6f 72 72 68 61 67 65 2e |olar hem|orrhage.|
|00005600| 0d 0a 0d 0a 20 20 20 20 | 20 43 61 73 65 20 31 2e |.... | Case 1.|
|00005610| 2d 2d 57 6f 6d 61 6e 2c | 20 36 30 2c 20 77 69 74 |--Woman,| 60, wit|
|00005620| 68 20 77 65 6c 6c 2d 64 | 6f 63 75 6d 65 6e 74 65 |h well-d|ocumente|
|00005630| 64 20 57 65 67 65 6e 65 | 72 27 73 20 67 72 61 6e |d Wegene|r's gran|
|00005640| 75 6c 6f 6d 61 74 6f 73 | 69 73 20 68 61 64 0d 0a |ulomatos|is had..|
|00005650| 61 6c 76 65 6f 6c 61 72 | 20 68 65 6d 6f 72 72 68 |alveolar| hemorrh|
|00005660| 61 67 65 20 34 20 77 65 | 65 6b 73 20 61 66 74 65 |age 4 we|eks afte|
|00005670| 72 20 6c 65 75 6b 6f 70 | 65 6e 69 61 20 6e 65 63 |r leukop|enia nec|
|00005680| 65 73 73 69 74 61 74 65 | 64 20 64 69 73 63 6f 6e |essitate|d discon|
|00005690| 74 69 6e 75 61 74 69 6f | 6e 20 6f 66 0d 0a 63 79 |tinuatio|n of..cy|
|000056a0| 63 6c 6f 70 68 6f 73 70 | 68 61 6d 69 64 65 2e 20 |clophosp|hamide. |
|000056b0| 20 53 68 65 20 77 61 73 | 20 73 65 65 6e 20 77 69 | She was| seen wi|
|000056c0| 74 68 20 73 6c 69 67 68 | 74 20 68 65 6d 6f 70 74 |th sligh|t hemopt|
|000056d0| 79 73 69 73 2c 20 64 79 | 73 70 6e 65 61 2c 20 77 |ysis, dy|spnea, w|
|000056e0| 65 69 67 68 74 20 6c 6f | 73 73 2c 0d 0a 61 6e 64 |eight lo|ss,..and|
|000056f0| 20 72 65 6e 61 6c 20 66 | 61 69 6c 75 72 65 2e 20 | renal f|ailure. |
|00005700| 20 43 68 65 73 74 20 72 | 61 64 69 6f 67 72 61 70 | Chest r|adiograp|
|00005710| 68 79 20 73 68 6f 77 65 | 64 20 64 69 66 66 75 73 |hy showe|d diffus|
|00005720| 65 20 61 6c 76 65 6f 6c | 61 72 20 69 6e 66 69 6c |e alveol|ar infil|
|00005730| 74 72 61 74 65 73 2e 20 | 20 41 6e 0d 0a 6f 70 65 |trates. | An..ope|
|00005740| 6e 2d 6c 75 6e 67 20 62 | 69 6f 70 73 79 20 73 70 |n-lung b|iopsy sp|
|00005750| 65 63 69 6d 65 6e 20 73 | 68 6f 77 65 64 20 64 69 |ecimen s|howed di|
|00005760| 66 66 75 73 65 20 61 6c | 76 65 6f 6c 61 72 20 68 |ffuse al|veolar h|
|00005770| 65 6d 6f 72 72 68 61 67 | 65 20 61 6e 64 20 63 61 |emorrhag|e and ca|
|00005780| 70 69 6c 6c 61 72 69 74 | 69 73 2e 0d 0a 54 68 65 |pillarit|is...The|
|00005790| 20 70 61 74 69 65 6e 74 | 20 69 6d 70 72 6f 76 65 | patient| improve|
|000057a0| 64 20 77 69 74 68 20 72 | 65 69 6e 73 74 69 74 75 |d with r|einstitu|
|000057b0| 74 69 6f 6e 20 6f 66 20 | 63 79 63 6c 6f 70 68 6f |tion of |cyclopho|
|000057c0| 73 70 68 61 6d 69 64 65 | 2e 0d 0a 20 20 20 20 20 |sphamide|... |
|000057d0| 43 61 73 65 20 32 2e 2d | 2d 4d 61 6e 2c 20 37 33 |Case 2.-|-Man, 73|
|000057e0| 2c 20 68 61 64 20 70 72 | 6f 67 72 65 73 73 69 76 |, had pr|ogressiv|
|000057f0| 65 20 64 79 73 70 6e 65 | 61 2c 20 68 65 6d 6f 70 |e dyspne|a, hemop|
|00005800| 74 79 73 69 73 2c 20 61 | 6e 6f 72 65 78 69 61 2c |tysis, a|norexia,|
|00005810| 20 77 65 69 67 68 74 0d | 0a 6c 6f 73 73 2c 20 61 | weight.|.loss, a|
|00005820| 6e 64 20 72 65 6e 61 6c | 20 66 61 69 6c 75 72 65 |nd renal| failure|
|00005830| 2e 20 20 4f 70 65 6e 2d | 6c 75 6e 67 20 62 69 6f |. Open-|lung bio|
|00005840| 70 73 79 20 73 70 65 63 | 69 6d 65 6e 73 20 73 68 |psy spec|imens sh|
|00005850| 6f 77 65 64 20 64 69 66 | 66 75 73 65 20 61 6c 76 |owed dif|fuse alv|
|00005860| 65 6f 6c 61 72 0d 0a 68 | 65 6d 6f 72 72 68 61 67 |eolar..h|emorrhag|
|00005870| 65 20 6f 76 65 72 73 68 | 61 64 6f 77 69 6e 67 20 |e oversh|adowing |
|00005880| 74 68 65 20 68 69 73 74 | 6f 6c 6f 67 69 63 20 66 |the hist|ologic f|
|00005890| 65 61 74 75 72 65 73 20 | 6f 66 20 57 65 67 65 6e |eatures |of Wegen|
|000058a0| 65 72 27 73 20 67 72 61 | 6e 75 6c 6f 6d 61 74 6f |er's gra|nulomato|
|000058b0| 73 69 73 2c 0d 0a 69 2e | 65 2e 2c 20 63 61 70 69 |sis,..i.|e., capi|
|000058c0| 6c 6c 61 72 69 74 69 73 | 2c 20 6e 65 63 72 6f 74 |llaritis|, necrot|
|000058d0| 69 7a 69 6e 67 20 67 72 | 61 6e 75 6c 6f 6d 61 73 |izing gr|anulomas|
|000058e0| 2c 20 61 6e 64 20 76 61 | 73 63 75 6c 69 74 69 73 |, and va|sculitis|
|000058f0| 2e 20 20 54 68 65 20 70 | 61 74 69 65 6e 74 27 73 |. The p|atient's|
|00005900| 0d 0a 63 6f 6e 64 69 74 | 69 6f 6e 20 64 65 74 65 |..condit|ion dete|
|00005910| 72 69 6f 72 61 74 65 64 | 20 72 61 70 69 64 6c 79 |riorated| rapidly|
|00005920| 20 61 6e 64 20 68 65 20 | 64 69 65 64 20 31 30 20 | and he |died 10 |
|00005930| 64 61 79 73 20 61 66 74 | 65 72 20 74 68 65 20 62 |days aft|er the b|
|00005940| 69 6f 70 73 79 2e 0d 0a | 4d 69 63 72 6f 73 63 6f |iopsy...|Microsco|
|00005950| 70 69 63 20 65 78 61 6d | 69 6e 61 74 69 6f 6e 20 |pic exam|ination |
|00005960| 6f 66 20 74 68 65 20 6c | 75 6e 67 73 20 73 68 6f |of the l|ungs sho|
|00005970| 77 65 64 20 63 61 70 69 | 6c 6c 61 72 69 74 69 73 |wed capi|llaritis|
|00005980| 20 61 6e 64 20 68 65 6d | 6f 72 72 68 61 67 65 2c | and hem|orrhage,|
|00005990| 20 62 75 74 20 6e 6f 0d | 0a 72 65 73 69 64 75 61 | but no.|.residua|
|000059a0| 6c 20 6e 65 63 72 6f 74 | 69 7a 69 6e 67 20 67 72 |l necrot|izing gr|
|000059b0| 61 6e 75 6c 6f 6d 61 74 | 6f 75 73 20 69 6e 66 6c |anulomat|ous infl|
|000059c0| 61 6d 6d 61 74 69 6f 6e | 20 6f 72 20 76 61 73 63 |ammation| or vasc|
|000059d0| 75 6c 69 74 69 73 2e 0d | 0a 0d 0a 20 20 20 20 20 |ulitis..|... |
|000059e0| 41 6c 76 65 6f 6c 61 72 | 20 68 65 6d 6f 72 72 68 |Alveolar| hemorrh|
|000059f0| 61 67 65 20 69 73 20 61 | 20 73 65 72 69 6f 75 73 |age is a| serious|
|00005a00| 2c 20 61 63 75 74 65 20 | 6d 61 6e 69 66 65 73 74 |, acute |manifest|
|00005a10| 61 74 69 6f 6e 20 6f 66 | 20 57 65 67 65 6e 65 72 |ation of| Wegener|
|00005a20| 27 73 0d 0a 67 72 61 6e | 75 6c 6f 6d 61 74 6f 73 |'s..gran|ulomatos|
|00005a30| 69 73 20 74 68 61 74 20 | 6d 61 79 20 62 65 20 6d |is that |may be m|
|00005a40| 6f 72 65 20 63 6f 6d 6d | 6f 6e 20 74 68 61 6e 20 |ore comm|on than |
|00005a50| 70 72 65 76 69 6f 75 73 | 6c 79 20 72 65 63 6f 67 |previous|ly recog|
|00005a60| 6e 69 7a 65 64 2e 20 20 | 54 68 65 0d 0a 64 69 61 |nized. |The..dia|
|00005a70| 67 6e 6f 73 69 73 20 6f | 66 20 70 75 6c 6d 6f 6e |gnosis o|f pulmon|
|00005a80| 61 72 79 20 68 65 6d 6f | 72 72 68 61 67 65 20 69 |ary hemo|rrhage i|
|00005a90| 6e 20 74 68 65 73 65 20 | 70 61 74 69 65 6e 74 73 |n these |patients|
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|00005ab0| 65 20 70 72 65 73 65 6e | 63 65 20 6f 66 0d 0a 68 |e presen|ce of..h|
|00005ac0| 65 6d 6f 70 74 79 73 69 | 73 2c 20 61 70 70 72 6f |emoptysi|s, appro|
|00005ad0| 70 72 69 61 74 65 20 72 | 61 64 69 6f 6c 6f 67 69 |priate r|adiologi|
|00005ae0| 63 20 73 69 67 6e 73 2c | 20 61 6e 64 20 61 20 72 |c signs,| and a r|
|00005af0| 61 69 73 65 64 20 74 72 | 61 6e 73 66 65 72 20 63 |aised tr|ansfer c|
|00005b00| 6f 65 66 66 69 63 69 65 | 6e 74 20 28 61 0d 0a 64 |oefficie|nt (a..d|
|00005b10| 69 66 66 75 73 69 6e 67 | 20 63 61 70 61 63 69 74 |iffusing| capacit|
|00005b20| 79 20 66 6f 72 20 63 61 | 72 62 6f 6e 20 6d 6f 6e |y for ca|rbon mon|
|00005b30| 6f 78 69 64 65 20 63 6f | 72 72 65 63 74 65 64 20 |oxide co|rrected |
|00005b40| 66 6f 72 20 61 6c 76 65 | 6f 6c 61 72 20 76 6f 6c |for alve|olar vol|
|00005b50| 75 6d 65 29 2e 20 20 57 | 68 65 6e 0d 0a 69 6e 74 |ume). W|hen..int|
|00005b60| 65 72 70 72 65 74 69 6e | 67 20 6c 75 6e 67 20 62 |erpretin|g lung b|
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|00005ba0| 72 20 68 65 6d 6f 72 72 | 68 61 67 65 2c 0d 0a 69 |r hemorr|hage,..i|
|00005bb0| 74 20 69 73 20 65 73 70 | 65 63 69 61 6c 6c 79 20 |t is esp|ecially |
|00005bc0| 69 6d 70 6f 72 74 61 6e | 74 20 74 6f 20 72 65 63 |importan|t to rec|
|00005bd0| 6f 67 6e 69 7a 65 20 74 | 68 65 20 70 72 65 73 65 |ognize t|he prese|
|00005be0| 6e 63 65 20 6f 66 20 63 | 61 70 69 6c 6c 61 72 69 |nce of c|apillari|
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|00005c00| 73 74 6f 6c 6f 67 69 63 | 20 66 65 61 74 75 72 65 |stologic| feature|
|00005c10| 73 20 6f 66 20 57 65 67 | 65 6e 65 72 27 73 20 67 |s of Weg|ener's g|
|00005c20| 72 61 6e 75 6c 6f 6d 61 | 74 6f 73 69 73 2c 20 73 |ranuloma|tosis, s|
|00005c30| 75 63 68 20 61 73 20 6e | 65 63 72 6f 74 69 7a 69 |uch as n|ecrotizi|
|00005c40| 6e 67 20 67 72 61 6e 75 | 6c 6f 6d 61 73 0d 0a 6f |ng granu|lomas..o|
|00005c50| 72 20 76 61 73 63 75 6c | 69 74 69 73 2e 20 20 43 |r vascul|itis. C|
|00005c60| 79 63 6c 6f 70 68 6f 73 | 70 68 61 6d 69 64 65 20 |yclophos|phamide |
|00005c70| 61 70 70 65 61 72 73 20 | 74 6f 20 62 65 20 65 66 |appears |to be ef|
|00005c80| 66 65 63 74 69 76 65 20 | 69 6e 20 6d 6f 73 74 20 |fective |in most |
|00005c90| 70 61 74 69 65 6e 74 73 | 2c 20 62 75 74 0d 0a 64 |patients|, but..d|
|00005ca0| 65 6c 61 79 20 69 6e 20 | 74 72 65 61 74 6d 65 6e |elay in |treatmen|
|00005cb0| 74 20 6d 61 79 20 62 65 | 20 66 61 74 61 6c 2e 0d |t may be| fatal..|
|00005cc0| 0a 0d 0a 50 6f 73 74 2d | 43 6f 6d 6d 65 6e 74 0d |...Post-|Comment.|
|00005cd0| 0a 0d 0a 20 20 20 20 20 | 54 68 69 73 20 69 73 20 |... |This is |
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|00005cf0| 74 69 63 6c 65 73 20 64 | 69 73 63 75 73 73 69 6e |ticles d|iscussin|
|00005d00| 67 20 64 69 66 66 75 73 | 65 20 61 6c 76 65 6f 6c |g diffus|e alveol|
|00005d10| 61 72 20 68 65 6d 6f 72 | 72 68 61 67 65 20 69 6e |ar hemor|rhage in|
|00005d20| 0d 0a 57 65 67 65 6e 65 | 72 27 73 20 67 72 61 6e |..Wegene|r's gran|
|00005d30| 75 6c 6f 6d 61 74 6f 73 | 69 73 2e 20 20 43 61 73 |ulomatos|is. Cas|
|00005d40| 65 20 31 20 69 6e 20 74 | 68 65 20 61 62 73 74 72 |e 1 in t|he abstr|
|00005d50| 61 63 74 65 64 20 61 72 | 74 69 63 6c 65 20 77 61 |acted ar|ticle wa|
|00005d60| 73 20 75 6e 64 65 72 20 | 74 72 65 61 74 6d 65 6e |s under |treatmen|
|00005d70| 74 0d 0a 66 6f 72 20 70 | 72 65 76 69 6f 75 73 6c |t..for p|reviousl|
|00005d80| 79 20 64 69 61 67 6e 6f | 73 65 64 20 57 65 67 65 |y diagno|sed Wege|
|00005d90| 6e 65 72 27 73 20 67 72 | 61 6e 75 6c 6f 6d 61 74 |ner's gr|anulomat|
|00005da0| 6f 73 69 73 20 61 6e 64 | 20 72 65 6c 61 70 73 65 |osis and| relapse|
|00005db0| 64 20 77 69 74 68 20 74 | 68 65 20 6e 65 77 20 61 |d with t|he new a|
|00005dc0| 6e 64 0d 0a 66 61 74 61 | 6c 20 6f 6e 73 65 74 20 |nd..fata|l onset |
|00005dd0| 6f 66 20 70 75 6c 6d 6f | 6e 61 72 79 20 68 65 6d |of pulmo|nary hem|
|00005de0| 6f 72 72 68 61 67 65 20 | 77 68 65 6e 20 63 79 63 |orrhage |when cyc|
|00005df0| 6c 6f 70 68 6f 73 70 68 | 61 6d 69 64 65 20 77 61 |lophosph|amide wa|
|00005e00| 73 20 64 69 73 63 6f 6e | 74 69 6e 75 65 64 2e 0d |s discon|tinued..|
|00005e10| 0a 4d 79 65 72 73 20 61 | 6e 64 20 4b 61 74 7a 65 |.Myers a|nd Katze|
|00005e20| 6e 73 74 65 69 6e 20 72 | 65 70 6f 72 74 20 61 20 |nstein r|eport a |
|00005e30| 36 32 2d 79 65 61 72 2d | 6f 6c 64 20 6d 61 6e 20 |62-year-|old man |
|00005e40| 77 68 6f 20 77 61 73 20 | 77 65 6c 6c 20 75 6e 74 |who was |well unt|
|00005e50| 69 6c 20 73 69 6e 75 73 | 69 74 69 73 20 61 6e 64 |il sinus|itis and|
|00005e60| 0d 0a 6f 74 69 74 69 73 | 20 64 65 76 65 6c 6f 70 |..otitis| develop|
|00005e70| 65 64 20 33 20 6d 6f 6e | 74 68 73 20 62 65 66 6f |ed 3 mon|ths befo|
|00005e80| 72 65 20 68 6f 73 70 69 | 74 61 6c 20 61 64 6d 69 |re hospi|tal admi|
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|00005eb0| 0a 77 65 69 67 68 74 20 | 6c 6f 73 73 2c 20 61 6e |.weight |loss, an|
|00005ec0| 64 20 68 65 6d 61 74 75 | 72 69 61 20 32 20 77 65 |d hematu|ria 2 we|
|00005ed0| 65 6b 73 20 62 65 66 6f | 72 65 20 61 64 6d 69 73 |eks befo|re admis|
|00005ee0| 73 69 6f 6e 20 61 6e 64 | 20 73 65 76 65 72 65 20 |sion and| severe |
|00005ef0| 68 65 6d 6f 70 74 79 73 | 69 73 20 77 69 74 68 0d |hemoptys|is with.|
|00005f00| 0a 61 6c 76 65 6f 6c 61 | 72 20 69 6e 66 69 6c 74 |.alveola|r infilt|
|00005f10| 72 61 74 65 73 20 6f 6e | 20 74 68 65 20 64 61 79 |rates on| the day|
|00005f20| 20 6f 66 20 61 64 6d 69 | 73 73 69 6f 6e 2e 20 5b | of admi|ssion. [|
|00005f30| 31 5d 20 20 4f 70 65 6e | 2d 6c 75 6e 67 20 62 69 |1] Open|-lung bi|
|00005f40| 6f 70 73 79 20 6f 6e 20 | 64 61 79 20 35 0d 0a 73 |opsy on |day 5..s|
|00005f50| 68 6f 77 65 64 20 6e 65 | 63 72 6f 74 69 7a 69 6e |howed ne|crotizin|
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|00005f70| 20 41 74 20 70 6f 73 74 | 6d 6f 72 74 65 6d 20 65 | At post|mortem e|
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|00005fc0| 20 72 65 70 6f 72 74 20 | 61 20 34 37 2d 79 65 61 | report |a 47-yea|
|00005fd0| 72 2d 6f 6c 64 20 6d 61 | 6e 20 77 68 6f 20 68 61 |r-old ma|n who ha|
|00005fe0| 64 20 66 6c 75 20 32 0d | 0a 77 65 65 6b 73 20 62 |d flu 2.|.weeks b|
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|00006020| 70 6f 78 65 6d 69 61 20 | 62 65 67 69 6e 6e 69 6e |poxemia |beginnin|
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|00006040| 20 61 64 6d 69 73 73 69 | 6f 6e 2c 20 61 20 64 69 | admissi|on, a di|
|00006050| 61 67 6e 6f 73 69 73 20 | 6f 66 20 57 65 67 65 6e |agnosis |of Wegen|
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|00006070| 73 69 73 20 62 61 73 65 | 64 20 6f 6e 20 61 6e 0d |sis base|d on an.|
|00006080| 0a 61 6e 74 69 63 79 74 | 6f 70 6c 61 73 6d 69 63 |.anticyt|oplasmic|
|00006090| 20 61 6e 74 69 62 6f 64 | 79 20 74 69 74 65 72 20 | antibod|y titer |
|000060a0| 6f 66 20 31 3a 35 31 32 | 2c 20 74 72 65 61 74 6d |of 1:512|, treatm|
|000060b0| 65 6e 74 20 77 69 74 68 | 20 63 79 63 6c 6f 70 68 |ent with| cycloph|
|000060c0| 6f 73 70 68 61 6d 69 64 | 65 20 66 72 6f 6d 0d 0a |osphamid|e from..|
|000060d0| 64 61 79 20 37 2c 20 64 | 69 61 6c 79 73 69 73 20 |day 7, d|ialysis |
|000060e0| 6f 6e 20 64 61 79 20 39 | 20 62 65 63 61 75 73 65 |on day 9| because|
|000060f0| 20 6f 66 20 70 72 6f 67 | 72 65 73 73 69 76 65 20 | of prog|ressive |
|00006100| 72 65 6e 61 6c 20 66 61 | 69 6c 75 72 65 2c 20 61 |renal fa|ilure, a|
|00006110| 6e 64 20 64 65 61 74 68 | 20 6f 6e 20 64 61 79 0d |nd death| on day.|
|00006120| 0a 31 37 2e 20 5b 32 5d | 0d 0a 20 20 20 20 20 54 |.17. [2]|.. T|
|00006130| 68 65 20 66 61 63 74 20 | 74 68 61 74 20 57 65 67 |he fact |that Weg|
|00006140| 65 6e 65 72 27 73 20 67 | 72 61 6e 75 6c 6f 6d 61 |ener's g|ranuloma|
|00006150| 74 6f 73 69 73 20 63 61 | 6e 20 63 61 75 73 65 20 |tosis ca|n cause |
|00006160| 64 69 66 66 75 73 65 20 | 61 6c 76 65 6f 6c 61 72 |diffuse |alveolar|
|00006170| 0d 0a 68 65 6d 6f 72 72 | 68 61 67 65 20 68 61 73 |..hemorr|hage has|
|00006180| 20 62 65 65 6e 20 6b 6e | 6f 77 6e 20 66 6f 72 20 | been kn|own for |
|00006190| 73 6f 6d 65 20 74 69 6d | 65 20 62 75 74 20 6e 6f |some tim|e but no|
|000061a0| 74 20 77 69 64 65 6c 79 | 20 61 70 70 72 65 63 69 |t widely| appreci|
|000061b0| 61 74 65 64 2e 20 20 41 | 20 73 65 72 69 65 73 20 |ated. A| series |
|000061c0| 6f 66 0d 0a 32 36 20 70 | 61 74 69 65 6e 74 73 20 |of..26 p|atients |
|000061d0| 77 69 74 68 20 64 69 66 | 66 75 73 65 20 61 6c 76 |with dif|fuse alv|
|000061e0| 65 6f 6c 61 72 20 68 65 | 6d 6f 72 72 68 61 67 65 |eolar he|morrhage|
|000061f0| 20 66 72 6f 6d 20 4d 69 | 6e 6e 65 73 6f 74 61 20 | from Mi|nnesota |
|00006200| 69 6e 63 6c 75 64 65 64 | 20 39 20 77 69 74 68 0d |included| 9 with.|
|00006210| 0a 76 61 73 63 75 6c 69 | 74 69 73 2c 20 33 20 6f |.vasculi|tis, 3 o|
|00006220| 66 20 77 68 6f 6d 20 68 | 61 64 20 57 65 67 65 6e |f whom h|ad Wegen|
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|00006240| 73 69 73 2e 20 20 54 6f | 20 67 69 76 65 20 73 6f |sis. To| give so|
|00006250| 6d 65 20 69 64 65 61 20 | 6f 66 0d 0a 72 65 6c 61 |me idea |of..rela|
|00006260| 74 69 76 65 20 66 72 65 | 71 75 65 6e 63 79 2c 20 |tive fre|quency, |
|00006270| 31 30 20 6f 66 20 74 68 | 65 20 32 36 20 70 61 74 |10 of th|e 26 pat|
|00006280| 69 65 6e 74 73 20 69 6e | 20 74 68 65 20 4d 69 6e |ients in| the Min|
|00006290| 6e 65 73 6f 74 61 20 72 | 65 70 6f 72 74 20 68 61 |nesota r|eport ha|
|000062a0| 64 0d 0a 61 6e 74 69 62 | 61 73 65 6d 65 6e 74 20 |d..antib|asement |
|000062b0| 6d 65 6d 62 72 61 6e 65 | 20 61 6e 74 69 62 6f 64 |membrane| antibod|
|000062c0| 79 20 64 69 73 65 61 73 | 65 2e 20 5b 33 2c 34 5d |y diseas|e. [3,4]|
|000062d0| 20 20 41 6e 6f 74 68 65 | 72 20 73 65 72 69 65 73 | Anothe|r series|
|000062e0| 20 6f 66 20 32 37 20 70 | 61 74 69 65 6e 74 73 0d | of 27 p|atients.|
|000062f0| 0a 77 69 74 68 20 61 6c | 76 65 6f 6c 61 72 20 68 |.with al|veolar h|
|00006300| 65 6d 6f 72 72 68 61 67 | 65 20 63 6f 6d 70 6c 69 |emorrhag|e compli|
|00006310| 63 61 74 69 6e 67 20 22 | 70 75 6c 6d 6f 6e 61 72 |cating "|pulmonar|
|00006320| 79 20 63 61 70 69 6c 6c | 61 72 69 74 69 73 22 20 |y capill|aritis" |
|00006330| 69 6e 63 6c 75 64 65 64 | 20 35 20 77 69 74 68 0d |included| 5 with.|
|00006340| 0a 57 65 67 65 6e 65 72 | 27 73 20 67 72 61 6e 75 |.Wegener|'s granu|
|00006350| 6c 6f 6d 61 74 6f 73 69 | 73 2c 20 5b 35 5d 20 61 |lomatosi|s, [5] a|
|00006360| 6e 64 20 61 6e 20 45 6e | 67 6c 69 73 68 20 73 74 |nd an En|glish st|
|00006370| 75 64 79 20 66 6f 75 6e | 64 20 61 6c 76 65 6f 6c |udy foun|d alveol|
|00006380| 61 72 20 68 65 6d 6f 72 | 72 68 61 67 65 20 69 6e |ar hemor|rhage in|
|00006390| 0d 0a 32 32 20 6f 66 20 | 35 33 20 70 61 74 69 65 |..22 of |53 patie|
|000063a0| 6e 74 73 20 77 69 74 68 | 20 74 68 61 74 20 64 69 |nts with| that di|
|000063b0| 73 65 61 73 65 2e 20 5b | 36 5d 0d 0a 20 20 20 20 |sease. [|6].. |
|000063c0| 20 22 50 75 6c 6d 6f 6e | 61 72 79 20 63 61 70 69 | "Pulmon|ary capi|
|000063d0| 6c 6c 61 72 69 74 69 73 | 22 20 61 6e 64 20 61 6c |llaritis|" and al|
|000063e0| 76 65 6f 6c 61 72 20 73 | 65 70 74 61 6c 20 6e 65 |veolar s|eptal ne|
|000063f0| 63 72 6f 73 69 73 20 61 | 72 65 20 6e 6f 74 20 73 |crosis a|re not s|
+--------+-------------------------+-------------------------+--------+--------+
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